TB-RECONNECT

The main objective of this project is to address deficiencies in current tuberculosis (TB) control programmes in order to accelerate its elimination. The aim is to better understand disease transmission, particularly in asymptomatic individuals with signs of active TB, and to generate high-resolution data on the contribution to the transmission burden of cases with different infection statuses. To achieve this, advances in host blood transcriptomics, pathogen genome sequencing, phylogenetic and epidemiological models, and bacterial population genetics and high-throughput functional genomics tools will be employed. The ultimate goal is to re-link transmission with tuberculosis control, which could inform important changes in control strategies at the global and local levels.